Actin-Related Protein 3 (Arp3)

Actin-Related Protein 3 (Arp3) [Homo Sapiens]

P: 61168: http://www.ncbi.nlm.nih.gov/protein/5031573

Family: Arp 3 belongs to actin family and Arp 3 subfamily, which consists of 20 proteins from different species. It is a subunit of ARP2/3 complex, along with Arp 2 and other 5 subunits, i.e. p40 (ARPC1), p35 (ARPC2), p19 (ARPC3), p18 (ARPC4), and p14 (ARPC5). It is found conserved within diverse eukaryotes. (1)

Function: Arp3 is associated with the polymerisation of the actin filaments together with the nucleation-promoting factor (NPF), by acting as ATP binding components.  Arp 3 and Arp 2 are brought together after the activation and therefore to form an actin-like nucleus for actin monomers binding and actin filaments elongation.  Arp 3 is in contact with the pointed end of daughter actin filaments and facilitates cillogenesis.  

It is involved in the formation of filopodium, establishment and maintenance of cell polarity, assembly and disassembly of myosin II filament, cytokinesis, spindle localization, cell motility, regulation of actin filament polymerization and neuron differentiation.

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